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ID: ALA1133381
Journal: Bioorg Med Chem Lett
Title: A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 2,3-disubstituted-4-phenylquinolines.
Authors: Tollefson MB, Vernier WF, Huang HC, Chen FP, Reinhard EJ, Beaudry J, Keller BT, Reitz DB.
Abstract: A series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds.
CiteXplore: 10698453