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ID: ALA1133383
Journal: Bioorg Med Chem Lett
Title: Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2.
Authors: Lucas R, Ubeda A, Payá M, Alves M, del Olmo E, López JL, San Feliciano A.
Abstract: We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhibitory profile against both types of PLA2 while no cytotoxicity at 10 microM on human neutrophils or on murine macrophage line was observed for both.
CiteXplore: 10698455