Secondary amines as new pharmacophores for macrofilaricidal drug design.

ID: ALA1133387

Journal: Bioorg Med Chem Lett

Title: Secondary amines as new pharmacophores for macrofilaricidal drug design.

Authors: Srivastava SK, Chauhan PM, Bhaduri AP, Murthy PK, Chatterjee RK.

Abstract: Several secondary amines exhibit promising macrofilaricidal response in vivo through oral route of administration against Acanthocheilonema viteae in which N-hexylcyclohexylamine (1) shows 100% macrofilaricidal activity while a tertiary amine such as 9 elicits predominantly microfilaricidal (93%) response.

CiteXplore: 10714488

DOI: 10.1016/s0960-894x(99)00687-3

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