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ID: ALA1133394
Journal: Bioorg Med Chem Lett
Title: Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues.
Authors: Subrahmanyam D, Sarma VM, Venkateswarlu A, Sastry TV, Srinivas AS, Krishna CV, Deevi DS, Kumar SA, Babu MJ, Damodaran NK.
Abstract: Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.
CiteXplore: 10714502