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ID: ALA1133432
Journal: Bioorg Med Chem Lett
Title: Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Authors: Coates PA, Grundt P, Robinson ES, Nutt DJ, Tyacke R, Hudson AL, Lewis JW, Husbands SM.
Abstract: An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function.
CiteXplore: 10741563