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ID: ALA1133433

Journal: Bioorg Med Chem Lett

Title: Synthesis of a novel class of cdc25A inhibitors from vitamin D3.

Authors: Dodo K, Takahashi M, Yamada Y, Sugimoto Y, Hashimoto Y, Shirai R.

Abstract: We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 microM) and caused GI arrest of HL60 cells.

CiteXplore: 10762037

DOI: 10.1016/s0960-894x(00)00065-2