Document Report Card
Basic Information
ID: ALA1133435
Journal: Bioorg Med Chem Lett
Title: Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor alpha agonists.
Authors: Hibi S, Tagami K, Kikuchi K, Yoshimura H, Tai K, Hida T, Tokuhara N, Yamauchi T, Nagai M.
Abstract: Synthesis and structure activity relationships (SAR) of RAR alpha-selective agonists are discussed. 4-[5-(5,8-Dimethyl-2H-3-chromenyl)-1H-2-pyrrolyl]benzoic acid (12a), which possesses a flat structural moiety and an oxygen atom at the hydrophobic part, showed highly selective transactivation activity at the RAR alpha receptor.
CiteXplore: 10762039