Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-ga...

ID: ALA1133438

Journal: Bioorg Med Chem Lett

Title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.

Authors: Guillou C, Mary A, Renko DZ, Gras E, Thal C.

Abstract: The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.

CiteXplore: 10762042

DOI: 10.1016/s0960-894x(00)00059-7

Patent ID: ┄