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ID: ALA1133496

Journal: Bioorg Med Chem Lett

Title: (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

Authors: Cecchetti V, Schiaffella F, Tabarrini O, Fravolini A.

Abstract: A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.

CiteXplore: 10743949

DOI: 10.1016/s0960-894x(00)00016-0