QSAR of 1,1'-(1,2-ethylenebisbenzyl)bis(4-substitutedpyridinium) dibromides as choline kinase inhibitors: a different approach for antiproliferative d...
Basic Information
ID: ALA1133498
Journal: Bioorg Med Chem Lett
Title: QSAR of 1,1'-(1,2-ethylenebisbenzyl)bis(4-substitutedpyridinium) dibromides as choline kinase inhibitors: a different approach for antiproliferative drug design.
Authors: Campos J, Núñez MC, Rodríguez V, Gallo MA, Espinosa A.
Abstract: Ten new structures of a series of the title compounds were synthesized and screened for their activity to inhibit choline kinase under ex vivo conditions. Their inhibitory potency correlates with the 13C chemical shifts (in CD3OD) of the methylene group bearing the positively charged nitrogen. The inhibitory effect on proliferation against the HT-29 cell line is strongly dependent on its ability to inhibit the production of phosphorylcholine.
CiteXplore: 10782682
DOI: 10.1016/s0960-894x(00)00080-9
Patent ID: ┄