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ID: ALA1133499
Journal: Bioorg Med Chem Lett
Title: Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
Authors: Arnaiz DO, Zhao Z, Liang A, Trinh L, Witlow M, Koovakkat SK, Shaw KJ.
Abstract: A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.
CiteXplore: 10853668