Document Report Card
Basic Information
ID: ALA1133781
Journal: Bioorg Med Chem Lett
Title: High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol.
Authors: Poulsen SA, Young DJ, Quinn RJ.
Abstract: The synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines has been performed by aromatic nucleophilic substitution of 4-amino-6-chloro-1-phenylpyrazolo[3,4-rd]pyrimidine under conditions of high pressure at ambient temperature. Conventional synthetic conditions (reflux at atmospheric pressure) were unsuccessful. The S enantiomer 11 displayed higher affinity and selectivity for the adenosine A1 receptor than the R enantiomer 12.
CiteXplore: 11206456