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ID: ALA1133790
Journal: Bioorg Med Chem Lett
Title: Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Authors: Levin JI, Gu Y, Nelson FC, Zask A, DiJoseph JF, Sharr MA, Sung A, Jin G, Cowling R, Chanda P, Cosmi S, Hsiao CL, Edris W, Wilhelm J, Killar LM, Skotnicki JS.
Abstract: Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.
CiteXplore: 11206468