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ID: ALA1133816
Journal: Bioorg Med Chem Lett
Title: Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.
Authors: Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC.
Abstract: A new family of potent N-alkoxyvinylsulfonamide inhibitors of cruzain have been developed. Inhibitor 13 has a second order inactivation rate constant of 6,480,000s(-1)M(-1) versus cruzain, and is also highly effective against Trypanosoma cruzi trypomastigotes in a tissue culture assay.
CiteXplore: 11591518