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ID: ALA1133827
Journal: Bioorg Med Chem Lett
Title: Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate.
Authors: Sedlák M, Buchta V, Kubicová L, Simůnek P, Holcapek M, Kasparová P.
Abstract: The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB possesses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
CiteXplore: 11597410