Basic Information
ID: ALA1133834
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of Pfmrk inhibitors as potential antimalarial agents.
Authors: Xiao Z, Waters NC, Woodard CL, Li Z, Li PK.
Abstract: The synthesis and inhibitory activities of 10 potential inhibitors of Pfmrk, a Plasmodium falciparum cyclin-dependent protein kinase, are described. The most potent inhibitor is a 3-phenyl-quinolinone compound with an IC(50) value of 18 microM. It is the first compound reported to inhibit Pfmrk at the micro molar range.
CiteXplore: 11597420
DOI: 10.1016/s0960-894x(01)00578-9
Patent ID: ┄
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