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ID: ALA1133842
Journal: Bioorg Med Chem Lett
Title: Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
Authors: Liu KG, Lambert MH, Leesnitzer LM, Oliver W, Ott RJ, Plunket KD, Stuart LW, Brown PJ, Willson TM, Sternbach DD.
Abstract: We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.
CiteXplore: 11677135