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ID: ALA1133847
Journal: Bioorg Med Chem Lett
Title: Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors.
Authors: Sirisoma NS, Ratra GS, Tomizawa M, Casida JE.
Abstract: Modification of the major insecticide fipronil (1) by replacing three pyrazole substituents (hydrogen for both cyano and amino and trifluoromethyldiazirinyl for trifluoromethylsulfinyl) gives a candidate photoaffinity probe (3) of high potency (IC(50) 2-28 nM) in blocking the chloride channel of Drosophila and human beta 3 GABA receptors.
CiteXplore: 11677140