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ID: ALA1133850

Journal: Bioorg Med Chem Lett

Title: Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.

Authors: Ahmed S, James K, Owen CP, Patel CK, Patel MB.

Abstract: Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

CiteXplore: 11714597

DOI: 10.1016/s0960-894x(01)00607-2