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ID: ALA1133850
Journal: Bioorg Med Chem Lett
Title: Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.
Authors: Ahmed S, James K, Owen CP, Patel CK, Patel MB.
Abstract: Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
CiteXplore: 11714597