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ID: ALA1133866
Journal: Bioorg Med Chem Lett
Title: Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Authors: Kim D, Wang L, Caldwell CG, Chen P, Finke PE, Oates B, MacCoss M, Mills SG, Malkowitz L, Gould SL, DeMartino JA, Springer MS, Hazuda D, Miller M, Kessler J, Danzeisen R, Carver G, Carella A, Holmes K, Lineberger J, Schleif WA, Emini EA.
Abstract: A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
CiteXplore: 11720851