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ID: ALA1133894
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Authors: Maruyama T, Asada M, Shiraishi T, Sakata K, Seki A, Yoshida H, Shinagawa Y, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M.
Abstract: Further chemical modification to identify more chemically stabilized EP4-receptor selective agonists was continued. As a result, a further two EP4-receptor selective agonists 5-thiaPGE(1) 2a, 10 and 9beta-chloroPGF(2) analogue 11 were discovered.
CiteXplore: 11454474