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ID: ALA1133904
Journal: Bioorg Med Chem Lett
Title: Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides.
Authors: Chen Z, Demuth TP, Wireko FC.
Abstract: Two well-defined oxidative chlorination-cyclization processes have been developed for the stereoselective synthesis of a variety of 4-amido-isothiazolidinone oxide derivatives. The stereochemistry of the cyclization products was confirmed by X-ray crystallography. These new compounds were designed as bacterial serine protease inhibitors. In tests, some of them showed weak antibacterial activity.
CiteXplore: 11514150