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ID: ALA1133925
Journal: Bioorg Med Chem Lett
Title: The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.
Authors: Reddick JJ, Saha S, Lee J, Melnick JS, Perkins J, Begley TP.
Abstract: The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.
CiteXplore: 11527707