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Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.

Basic Information

ID: ALA1133930

Journal: Bioorg Med Chem Lett

Title: Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.

Authors: Kordik CP, Luo C, Zanoni BC, Lovenberg TW, Wilson SJ, Vaidya AH, Crooke JJ, Rosenthal DI, Reitz AB.

Abstract: 1-Aryl-3-carboxamido-5-alkylpyrazoles were prepared based on a hit found in high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. 1-(3-Trifluoromethylphenyl)-3-[N-(5-quinolinyl)carboxamido]-5-methylpyrazole (31) bound to the human neuropeptide Y5 receptor with a 80 nM IC(50 )and was shown to inhibit cumulative food consumption 43.2% 2-6 h after ip dosing in a fasting-induced feeding model in rats.

CiteXplore: 11527716

DOI: 10.1016/s0960-894x(01)00449-8

Patent ID: