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ID: ALA1133953
Journal: Bioorg Med Chem Lett
Title: Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.
Authors: Chibale K, Ojima I, Haupt H, Geng X, Pera P, Bernacki RJ.
Abstract: Sulfonamide derivatives of chloroquine and primaquine were synthesised and evaluated against both paclitaxel-sensitive and paclitaxel-resistant mammarian cancer cell lines. All derivatives exhibited at least 96% MDR reversal activity when co-administered with paclitaxel at 5 microM. The best compound, a chloroquine derivative, exhibited 99% MDR reversal activity when co-administered with paclitaxel at 1 microM. Molecular modelling studies reveal that these derivatives share a common pharmacophore with taxane MDR reversal agents.
CiteXplore: 11549446