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ID: ALA1133954
Journal: Bioorg Med Chem Lett
Title: The discovery of novel, potent and selective PDE5 inhibitors.
Authors: Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE.
Abstract: The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC50=0.31 nM) and selective (>10,000-fold vs PDE1 and 160-fold selective vs PDE6) PDE5 inhibitor than sildenafil.
CiteXplore: 11549447