Document Report Card
Basic Information
ID: ALA1133973
Journal: Bioorg Med Chem Lett
Title: Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
Authors: Pratt LM, Beckett RP, Davies SJ, Launchbury SB, Miller A, Spavold ZM, Todd RS, Whittaker M.
Abstract: By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.
CiteXplore: 11551755