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ID: ALA1133974
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1.
Authors: Folkes A, Roe MB, Sohal S, Golec J, Faint R, Brooks T, Charlton P.
Abstract: We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited PAI-1 in vitro with an IC(50)=0.2 microM. The synthesis and SAR of these compounds are described.
CiteXplore: 11551756