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ID: ALA1133984
Journal: Bioorg Med Chem Lett
Title: Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.
Authors: Zhao LX, Kim TS, Ahn SH, Kim TH, Kim EK, Cho WJ, Choi H, Lee CS, Kim JA, Jeong TC, Chang CJ, Lee ES.
Abstract: For the development of new anticancer agents, 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2':6',2"-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives were potent topoisomerase I inhibitors.
CiteXplore: 11551772