Basic Information
ID: ALA1133985
Journal: Bioorg Med Chem Lett
Title: Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists.
Authors: Yoneda Y, Kawajiri S, Sugimura M, Osanai K, Kito F, Ota E, Mimura T.
Abstract: We synthesized diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca(2+)-permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.
CiteXplore: 11551773
DOI: 10.1016/s0960-894x(01)00530-3
Patent ID: ┄
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