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ID: ALA1133990

Journal: Bioorg Med Chem Lett

Title: 8-Amido-Bearing pseudomycin B (PSB) analogue: novel antifungal agents.

Authors: Zhang YZ, Sun X, Zeckner DJ, Sachs RK, Current WL, Chen SH.

Abstract: During the course of a structure-activity relationship (SAR) study on novel depsinonapeptide pseudomycin B, we synthesized a total of 12 8-amidopseudomycin analogues via standard two-step sequence from either ZPSB 2 or AllocPSB 3. A number of these amides exhibited good in vitro antifungal activities.

CiteXplore: 11206441

DOI: 10.1016/s0960-894x(00)00606-5