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ID: ALA1133995
Journal: Bioorg Med Chem Lett
Title: Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Authors: Pendergast W, Yerxa BR, Douglass JG, Shaver SR, Dougherty RW, Redick CC, Sims IF, Rideout JL.
Abstract: A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.
CiteXplore: 11206448