Document Report Card
Basic Information
ID: ALA1134004
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues.
Authors: Kokotos G, Constantinou-Kokotou V, Padrón JM, Peters GJ.
Abstract: Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.
CiteXplore: 11277538