Document Report Card

Basic Information

ID: ALA1134004

Journal: Bioorg Med Chem Lett

Title: Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues.

Authors: Kokotos G, Constantinou-Kokotou V, Padrón JM, Peters GJ.

Abstract: Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.

CiteXplore: 11277538

DOI: 10.1016/s0960-894x(01)00084-1