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ID: ALA1134013
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of benzo[b]naphthyridones, a series of new topical antibacterial agents.
Authors: Tabart M, Picaut G, Desconclois JF, Dutka-Malen S, Huet Y, Berthaud N.
Abstract: We describe here the synthesis and biological evaluation of a series of benzo[b]naphthyridones, a new family of tricyclic antibacterial compounds that have a gram-positive spectrum of activity. RP60556A, one of the most potent of these compounds, is bactericidal against multiresistant cocci, especially multiresistant Staphylococcus aureus strains. Its physico-chemical and biological properties make it particularly suitable for topical antibacterial use.
CiteXplore: 11294391