Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.

ID: ALA1134021

Journal: Bioorg Med Chem Lett

Title: Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.

Authors: Beaton H, Boughton-Smith N, Hamley P, Ghelani A, Nicholls DJ, Tinker AC, Wallace AV.

Abstract: 5-Substituted 7-amino-4,5-tetrahydrothieno[2,3-c]pyridines and 6-substituted 4-amino-6,7-dihydrothieno[3,2-c]pyridines were shown to be exceptionally potent inhibitors of inducible and neuronal nitric oxide synthase. Selectivity and potency could be modulated by variation of the 5- or 6-substituent. Compound 3e showed potent in vivo inhibition of iNOS.

CiteXplore: 11327581

DOI: 10.1016/s0960-894x(01)00120-2

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