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ID: ALA1134033

Journal: Bioorg Med Chem Lett

Title: Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

Authors: Lee J, Kang SU, Kim SY, Kim SE, Kang MK, Jo YJ, Kim S.

Abstract: The structure activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1'-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.

CiteXplore: 11327600

DOI: 10.1016/s0960-894x(01)00095-6