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ID: ALA1134043
Journal: Bioorg Med Chem Lett
Title: Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.
Authors: Wright SW, Hageman DL, McClure LD, Carlo AA, Treadway JL, Mathiowetz AM, Withka JM, Bauer PH.
Abstract: Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site.
CiteXplore: 11140724