Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

ID: ALA1134049

Journal: Bioorg Med Chem Lett

Title: Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

Authors: Lawrence NJ, Rennison D, Woo M, McGown AT, Hadfield JA.

Abstract: A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.

CiteXplore: 11140732

DOI: 10.1016/s0960-894x(00)00596-5

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