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ID: ALA1134063
Journal: Bioorg Med Chem Lett
Title: Identification of a potent and selective oxytocin antagonist, from screening a fully encoded differential release combinatorial chemical library.
Authors: Evans B, Pipe A, Clark L, Banks M.
Abstract: A library of 1,296 1,4-benzodiazepines was prepared on 160 microM Tentagel beads. Compounds are attached to the beads using orthogonally cleavable linkers. The library was first screened as pools of 30 beads where 50% of the material is released and screened. GW405212X, a selective oxytocin antagonist, was identified by picking single beads from active pools.
CiteXplore: 11392541