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ID: ALA1134064
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist.
Authors: Wyatt PG, Allen MJ, Chilcott J, Hickin G, Miller ND, Woollard PM.
Abstract: We have investigated the structure-activity relationships of the 1- and 3-substituents and replacements of the 5-phenyl group of GW405212X 1, a potent selective oxytocin antagonist. The effect of these modifications on oxytocin binding antagonism and on pharmacokinetic parameters is reported.
CiteXplore: 11392542