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ID: ALA1134099
Journal: Bioorg Med Chem Lett
Title: Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Authors: Grunewald GL, McLeish MJ, Criscione KR.
Abstract: Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PNMT) catalyzes the final step in the biosynthesis of Epi and is thus a pharmacological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brain PNMT for a number of substrates and inhibitors are examined and the results reported.
CiteXplore: 11412985