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ID: ALA1134135
Journal: Bioorg Med Chem Lett
Title: Nitrobenzene compounds inhibit expression of VCAM-1.
Authors: Meng CQ, Zheng XS, Holt LA, Hoong LK, Somers PK, Hill RR, Saxena U.
Abstract: A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.
CiteXplore: 11459640