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ID: ALA1134135

Journal: Bioorg Med Chem Lett

Title: Nitrobenzene compounds inhibit expression of VCAM-1.

Authors: Meng CQ, Zheng XS, Holt LA, Hoong LK, Somers PK, Hill RR, Saxena U.

Abstract: A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.

CiteXplore: 11459640

DOI: 10.1016/s0960-894x(01)00306-7