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ID: ALA1134156
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.
Authors: Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Amori L, Josef Flor P, Gasparini F, Kuhn R, Urwyler S.
Abstract: Two novel 3'-substituted carboxycylopropylglycines, (2S,1'S,2'S,3'R)-2-(3'-xanthenylmethyl-2'-carboxycyclopropyl)glycine (8a) and (2S,1'S,2'S,3'R)-2-(3'-xanthenylethyl-2'-carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity.
CiteXplore: 11720869