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ID: ALA1134166
Journal: Bioorg Med Chem Lett
Title: The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.
Authors: Bennett JM, Campbell AD, Campbell AJ, Carr MG, Dunsdon RM, Greening JR, Hurst DN, Jennings NS, Jones PS, Jordan S, Kay PB, O'Brien MA, King-Underwood J, Raynham TM, Wilkinson CS, Wilkinson TC, Wilson FX.
Abstract: Peptides based upon the non-prime side residues of the NS4A-4B cleavage site of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha-ketoamide moiety in place of the scissile amide bond are potent inhibitors of this enzyme.
CiteXplore: 11212109