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ID: ALA1134173
Journal: Bioorg Med Chem Lett
Title: FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties.
Authors: Fujie A, Iwamoto T, Sato B, Muramatsu H, Kasahara C, Furuta T, Hori Y, Hino M, Hashimoto S.
Abstract: The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379.
CiteXplore: 11212120