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ID: ALA1134176
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.
Authors: Wiesner J, Mitsch A, Wissner P, Jomaa H, Schlitzer M.
Abstract: We have described compound 1 as a lead structure for a novel class of anti-malarial agents. Replacement of the 3-phenylpropionyl moiety of the lead structure 1 by a 4-propoxycinnamic acid residue resulted in a significant improvement in antimalarial activity. Compound 3q represents an important step in the development of lead structure 1 into an anti-malarial drug candidate.
CiteXplore: 11212126