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ID: ALA1134180
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives.
Authors: Xiao S, Lin W, Wang C, Yang M.
Abstract: A series of 3-substituted-beta-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results.
CiteXplore: 11229742