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ID: ALA1134190
Journal: Bioorg Med Chem Lett
Title: Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.
Authors: Ting PC, Lee JF, Anthes JC, Shih NY, Piwinski JJ.
Abstract: The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.
CiteXplore: 11229755