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ID: ALA1134197
Journal: Bioorg Med Chem Lett
Title: A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase.
Authors: Yu XY, Hill JM, Yu G, Yang Y, Kluge AF, Keith D, Finn J, Gallant P, Silverman J, Lim A.
Abstract: A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50 = 5 nM (Ca. ProRS) with high selectivity over the human enzyme.
CiteXplore: 11229766