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ID: ALA1134199

Journal: Bioorg Med Chem Lett

Title: Peptoids as endothelin receptor antagonists.

Authors: Dasgupta F, Gangadhar N, Bruhaspathy M, Verma AK, Sarin S, Mukherjee AK.

Abstract: A series of new peptoids as endothelin receptor antagonists has been synthesized. Screening them for their ability to bind with endothelin receptors (ET(A) and ET(B)) competitively in the presence of (125I) endothelin led to the discovery of compounds as possible leads with IC50s in the low micromolar concentrations.

CiteXplore: 11229770

DOI: 10.1016/s0960-894x(01)00009-9